textual criticism & genetic mutations

People having been miscopying text for thousands of years. And understanding the errors in these manuscripts is actually quite similar to understanding genetics. This sounds a bit odd. What do handwritten manuscripts, from the medieval period or earlier, have to do with genetics? On the surface, nothing: one is a hard experimental science and the other is a distinguished part of the humanities. However, while those who study each of these fields have very little to do with each other, it turns out that there is a great deal of symmetry. And it mainly comes down to mutation. Scholars who study paleography - the field of research that examines ancient writing - are all-too-well-aware of the mistakes that scribes make when copying a text. These types of errors, which can be used to understand the provenance of a history of a document, are actually nearly identical to the types of errors caused by polymerase enzymes, the proteins responsible for copying DNA strands. It's clear what a mutation is in genetics: a strand of DNA gets hit by a cosmic ray, or copied incorrectly, and some error gets introduced into the sequence. For example, an 'A' gets turned into a 'G', although they can be much larger in effect. These errors can range from causing no problem whatsoever (don't worry - the majority are like this), to causing large-scale issues due to the change in a single letter of DNA, such as in the case of sickle-cell anemia.

Well, there are also systematic errors in copying a text. Whether it's skipping a word or duplicating it, there is order to the ways in which a scribe's mind wanders during his transcription. Many of the errors can be grouped into categories of error, just like the different types of genetic mutations. And not only are there regularities to how both DNA and ancient manuscripts are copied, but it gets even better: despite the differences in terms, these types of errors are often identical.

via The Atlantic.